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. 2021 Jun 7;11(6):849. doi: 10.3390/biom11060849

Figure 1.

Figure 1

Structure of Notch receptors and ligands. (A) The four human Notch receptors (NOTCH1-4) are structurally similar. All receptors possess extracellular domains, and all four receptors share similarity in the intracellular domain, but NOTCH4 lacks the TAD domain. (B) All human Notch ligands of both the Delta-Like and Jagged families contain a DSL. The Notch ligand families can be distinguished by the number of EGF-like extracellular domains. Unique to the Jagged family is a 24 amino acid insertion between the 10th and 11th EGF-like domains of JAGGED1 and JAGGED2. The cysteine-rich region is another unique feature of the Jagged family ligands. At the C-terminus of DLL1, DLL4, and JAGGED1 is a PDZ motif. EGF: Epidermal growth factor; LNR: lin-12/Notch repeats; HD: Heterodimerization domain; NRR: Negative regulatory region; RAM: RBPjκ association module; NLS: Nuclear localization signal; TAD: Transcriptional activation domain; PEST: Proline (P), Glutamic acid (E), Serine (S), Threonine (T) rich domain; DLL: Delta-like; DSL: Delta/Serrate/LAG- 2 domain; PDZ: Post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and Zonula occludens-1 (ZO-1).