Table 1.
Knockout mouse models of the Notch signaling pathway.
| Knockout | Genotype | Embryonic Lethality | Developmental Impairment | References |
|---|---|---|---|---|
| Notch1 | −/− | Yes (E9.5) | Somitogenesis Neurogenesis Developmental impairment |
[24,25] |
| Notch2 | −/− | Yes (E11.5) | Wide-spread pycnosis and apoptosis | [26] |
| Notch3 | −/− | No | Vascular and arterial development | [27] |
| Notch1 & Notch3 |
Notch1: −/− Notch3: −/− |
Yes (E9.5) | Somitogenesis Neurogenesis Developmental impairment |
[28] |
| Notch4 | −/− | No | Vasculature of embryonic head | [29,30] |
| Notch1 & Notch4 |
Notch1: −/− Notch4: −/− |
Yes (E10.5) | Vascular development Developmental impairment (more severe than Notch1 knockout) |
[29] |
| Dll1 | −/− | Yes (E10–E12) | Somitogenesis | [31] |
| Dll3 | −/− | Yes (~20%) | Somitogenesis Skeletal deformities |
[32] |
| Dll4 | −/− | Yes (E8.5) | Vascular and arterial development | [33] |
| Dll4 | +/− | Yes (E9.5–E10.5) | Vascular and arterial development | [33,34,35] |
| Jagged1 | −/− | Yes (E10.5) | Vascular development | [36] |
| Jagged2 | −/− | Yes (E10.5) | Craniofacial and skeletal deformities | [37,38] |
| Cbf1 | −/− | Yes (E8.5) | Somitogenesis Placenta defects |
[23] |
| Adam10 | −/− | Yes (E9.5) | Somitogenesis Heart and neural defects |
[17] |
| Adam17/Tace | −/− | Yes (E17.5) | Eyes and lungs defects | [16] |
−/−: Homozygous Knockout; +/−: Heterozygous Knockout; Adam10: A disintegrin and metalloproteases 10; Cbf1: C-promoter binding factor 1; Dll: Delta-like; E: postimplantation days; Jag: Jagged; Tace: ADAM17/Tumor-necrosis-factor (TNF) α converting enzyme.