Figure 2.

Schematic representation of chromosome 1 indicating the location of the possible genetic driver genes in this region, denoted by colored lines. The amplification of the 1q21 region results in the simultaneous overexpression of several genes leading to disease progression, MM cell survival, and an increase in genomic instability. BCL9, B cell lymphoma 9; MCL-1, myeloid cell leukemia-1; ILF2, interleukin enhancer binding factor 2; IL6R, interleukin-6 receptor; and CKS1B, CDC28 protein kinase regulatory subunit 1B.