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Diagram of the development of proliferative vitreoretinopathy (PVR). (A). As a result of tissue injury and retinal disruption, the neurosensory layer of the retina separates from the retinal pigment epithelium (RPE). (B). RPE cells migrate through the retinal break towards the vitreous chamber. (C). RPE cells transdifferentiate to fibroblasts and then begin to proliferate and produce collagen, forming fibrous membranes that cover and overgrow the retina.
