Table 4.

A summary of the identified associations of Eph and ephrins with choroidal neovascularization.

Name	Established Association with Choroidal Neovascularization	Possible Mechanism	Possible Use in Clinical Practice	Reference
EphA7	Expression in neovascular membranes	Possible association with the pathogenesis of CNV	Potential therapeutic target	[76]
ephrinB2 and EphB4	Expression in choroidal endothelial cells Reduction in the leakage score of CNV membranes following intravitreal administration of a soluble form of EphB4	Role in maintaining the stability of the vessels Inhibition of choroidal endothelial cells migration	Potential therapeutic target	[62]
EphB4	Reduction in the leakage score of CNV membranes following intravitreal administration of soluble form of EphB4 Reduction of VEGF following intravitreal administration of a soluble form of EphB4	Inhibition of choroidal endothelial cells migration Connection of VEGF and Eph signaling pathways	Potential therapeutic target	[77]
EphB4	Slowing the progression of CNV following intravitreal administration of EphB4 monoclonal antibody	Possible association with the pathogenesis of choroidal neovascularization	Potential therapeutic target	[78]