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. 2021 May 29;10(6):483. doi: 10.3390/biology10060483

Figure 3.

Figure 3

Comparative analysis of HCV proteins in hepatocytes of patients with chronic hepatitis C coinfected or not infected with herpesviruses. (a) Immunohistochemical detection of HCV proteins in cryostat liver sections using a mixture of mAbs to the core, NS3, NS4A/B, and NS5A proteins (A–D, F); E—mAb to HBsAg (negative control). A–E: patients with CHC, F: patient with steatohepatitis (negative control). Note more intensive cytoplasmic staining (brown) in group 1—HHV detected (A, B) compared with group 2—HHV not detected (C, D). No immunoreactivity was observed in the controls (E, F). The cell nuclei were stained with hematoxylin (blue). Magnification, × 400. (b) The relative number of HCV-containing liver cells in patients with CHC, depending on the detection of herpesviruses. Values are the means ± SEM (b), * p < 0.05 between groups.