Table 2.

Gene list of decreased expression in limb skeletal muscle from Black (n = 9) and White (n = 5) patients with CLI.

Gene symbol	Gene name	Fold change (from CLI-W)	p-value	FDR
PTX3	pentraxin 3, long	−36.48	0.00000012	0.0008592
FBP1	fructose-1,6-bisphosphatase 1	−12.08	0.00000015	0.0008592
CA12	carbonic anhydrase XII	−23.65	0.00000030	0.0008592
ALPL	alkaline phosphatase, liver/bone/kidney	−21.46	0.00000031	0.0008592
ANPEP	alanyl (membrane) aminopeptidase	−14.46	0.00000034	0.0008592
AQP9	aquaporin 9	−21.45	0.00000045	0.0009670
CEMIP	cell migration inducing protein, hyaluronan binding	−22.37	0.00000054	0.0010137
THBS1	thrombospondin 1	−12.24	0.00000109	0.0018099
FADS1	fatty acid desaturase 1	−3.98	0.00000134	0.00200833
MMP9	matrix metallopeptidase 9	−32.93	0.00000263	0.0033987
SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3	−5.85	0.00000281	0.00339869
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	−11.28	0.00000295	0.00339869
SRGN	serglycin	−5.82	0.00000435	0.0045012
ST14	suppression of tumorigenicity 14 (colon carcinoma)	−17.74	0.00000452	0.0045012
ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	−8.87	0.00000747	0.00658073
CLIC6	chloride intracellular channel 6	−9.92	0.00000779	0.00658073
PLAUR	plasminogen activator, urokinase receptor	−9.16	0.00000792	0.00658073
TIMP1	TIMP metallopeptidase inhibitor 1	−10.37	0.00000916	0.00672507
STC1	stanniocalcin 1	−11.44	0.00000937	0.00672507
CD52	CD52 molecule	−7.55	0.00000990	0.00672507

List generated from WTSS data, sorted by significance (p-value), and the top 20 targets represented.

Fold change representative of target message counts.

CLI, critical limb ischemia; FDR, false discovery rate; W, White; WTSS, whole transcriptome shotgun sequencing.