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Cell growth inhibitory activity of selinexor in TNBC cell lines.
| Cell Line | IC50 (µM) 1 | ||
|---|---|---|---|
| 24 h | 48 h | 72 h | |
| MDA-MB-231 | >10 | >10 | 0.05 ± 0.02 |
| SUM-159 | >10 | 3.1 ± 1.1 | 0.12 ± 0.04 |
| HCC1937 | >10 | >10 | 1.04 ± 0.03 |
| MDA-MB-468 | 3.7 ± 1.4 | 0.18 ± 0.06 | 0.03 ± 0.02 |
1 Concentration of drug required to inhibit cell growth by 50% (IC50), as determined after continuous exposure to selinexor for different time intervals. Data represent the mean ± SD of three independent experiments.
