Table 2.
OB DEPs in MixD previously related with AD and/or vascular damage. FC; fold change. Unique peptides correspond to the number of exclusive peptides that have been used for the protein quantitation of each protein. The biological involvement information derived from the Metascape output files.
| Protein Names | Gene Name | FC | p Value | Unique Peptides | Biological Involvement |
|---|---|---|---|---|---|
| Collagen alpha-2(I) chain | COL1A2 | 0.20 | 0.000 | 4 | blood vessel development, interactions at the vascular wall, coagulation |
| Cadherin-13 | CDH13 | 0.32 | 0.006 | 3 | cardiovascular & blood vessel development |
| G protein-regulated inducer of neurite outgrowth 1 | GPRIN1 | 0.39 | 0.008 | 24 | AD |
| Calmodulin | CALM | 0.45 | 0.006 | 12 | AD, VEGFR2 mediated vascular permeability, atherosclerosis |
| Disintegrin and metalloproteinase domain-containing protein 10 | ADAM10 | 0.48 | 0.022 | 10 | AD, cardiovascular development |
| Synaptosomal-associated protein 25 | SNAP25 | 0.48 | 0.000 | 16 | Cognition, learning/memory |
| Secretogranin-2 | SCG2 | 0.54 | 0.021 | 15 | cardiovascular & blood vessel development |
| Proto-oncogene tyrosine-protein kinase Src | SRC | 0.54 | 0.017 | 5 | interactions at the vascular wall, atherosclerosis, coagulation |
| Serine/threonine-protein phosphatase 2B catalytic subunit gamma | PPP3CC | 0.54 | 0.015 | 4 | AD |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | NDUFS4 | 0.54 | 0.002 | 6 | AD |
| Integrin beta-8 | ITGB8 | 0.56 | 0.014 | 3 | cardiovascular & blood vessel development |
| Neurexin-3 | NRXN3 | 0.58 | 0.000 | 18 | Cognition, learning/memory |
| Contactin-associated protein-like 2 | CNTNAP2 | 0.58 | 0.007 | 12 | Cognition, learning/memory |
| Thy-1 membrane glycoprotein | THY1 | 0.62 | 0.005 | 4 | cardiovascular & blood vessel development |
| Rap guanine nucleotide exchange factor 2 | RAPGEF2 | 0.63 | 0.043 | 11 | cardiovascular & blood vessel development |
| Cytochrome c oxidase subunit 5B, mitochondrial | COX5B | 0.63 | 0.002 | 6 | AD |
| Protein kinase C gamma type | PRKCG | 0.63 | 0.029 | 23 | Cognition, learning/memory, coagulation |
| Dematin | DMTN | 0.65 | 0.023 | 10 | coagulation |
| Glypican-1 | GPC1 | 0.65 | 0.048 | 9 | interactions at the vascular wall, atherosclerosis |
| ATP synthase subunit delta, mitochondrial | ATP5D | 0.67 | 0.025 | 5 | AD |
| von Willebrand factor | VWF | 0.68 | 0.046 | 11 | coagulation |
| Tyrosine-protein phosphatase non-receptor type substrate 1 | SIRPA | 0.68 | 0.002 | 18 | interactions at the vascular wall |
| Cytochrome b-c1 complex subunit 7 | UQCRB | 0.69 | 0.006 | 8 | AD |
| Ras-related C3 botulinum toxin substrate 1 | RAC1 | 0.72 | 0.006 | 4 | VEGFR2 mediated vascular permeability, atherosclerosis, coagulation |
| cGMP-dependent 3,5-cyclic phosphodiesterase | PDE2A | 0.73 | 0.001 | 26 | cardiovascular & blood vessel development |
| Reticulon-3 | RTN3 | 0.73 | 0.000 | 7 | AD |
| Protein-tyrosine kinase 2-beta | PTK2B | 0.74 | 0.049 | 19 | cardiovascular & blood vessel development |
| Microtubule-associated protein tau | MAPT | 1.39 | 0.048 | 8 | AD, cognition, learning/memory |
| 4F2 cell-surface antigen heavy chain | SLC3A2 | 1.43 | 0.000 | 28 | interactions at the vascular wall |
| Glutathione S-transferase P | GSTP1 | 1.47 | 0.000 | 15 | atherosclerosis |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | PLCD3 | 1.55 | 0.030 | 17 | cardiovascular & blood vessel development |
| Aquaporin-1 | AQP1 | 1.56 | 0.006 | 3 | cardiovascular & blood vessel development |
| Peptidyl-prolyl cis-trans isomerase A | PPIA | 1.56 | 0.005 | 13 | interactions at the vascular wall, coagulation |
| Tenascin-R | TNR | 1.57 | 0.006 | 46 | Cognition, learning/memory |
| Ectonucleoside triphosphate diphosphohydrolase 2 | ENTPD2 | 1.60 | 0.040 | 11 | coagulation |
| Cysteine and glycine-rich protein 1 | CSRP1 | 1.73 | 0.000 | 12 | coagulation |
| BH3-interacting domain death agonist | BID | 1.74 | 0.040 | 5 | AD |
| Microsomal glutathione S-transferase 3 | MGST3 | 2.03 | 0.000 | 7 | atherosclerosis |
| AP-3 complex subunit beta-1 | AP3B1 | 2.45 | 0.019 | 13 | coagulation |
| Protein S100-A1 | S100A1 | 2.65 | 0.014 | 4 | cardiovascular & blood vessel development |
| Cytochrome b-c1 complex subunit 9 | UQCR10 | 2.72 | 0.000 | 2 | AD |
| Prolow-density lipoprotein receptor-related protein 1 | LRP1 | 3.98 | 0.011 | 37 | AD, cardiovascular & blood vessel development |
| High mobility group protein B1 | HMGB1 | 4.04 | 0.015 | 7 | cardiovascular & blood vessel development |
| Protein S100-B | S100B | 4.05 | 0.001 | 4 | Cognition, learning/memory |