Figure 1.

Coverage of uORF-associated uAUG, aTIS, and uStop codons in WES datasets. Dot plots indicating the proportion of genomic positions of canonical (uAUG) and alternative initiation sites (aTISs), as well as the associated termination codons (uStops) covered by ≥10 reads in tumor (orange dots) and normal control (grey dots) patient samples. The coverage analysis was performed using TCGA-derived whole-exome sequencing BAM files of (a) breast invasive carcinoma (BRCA), (b) colon adenocarcinoma (COAD), (c) lung adenocarcinoma (LUAD), (d) prostate adenocarcinoma (PRAD), (e) skin cutaneous melanoma (SKCM), (f) acute myeloid leukemia (LAML), and the related normal controls. Orange and black lines indicate the median coverage of entity-specific tumor and normal control samples, respectively.