Table 1.

Summary of screened uORF-associated genomic positions, analyzed types of cancer, and identified SNVs affecting uAUG, aTIS, and uStop codons.

	uORF-Associated Nucleotides in hg38 uAUG: 190,878 aTIS: 2,515,399 uStop: 624,157
Type of Cancer	BRCA	COAD	LUAD	PRAD	SKCM	LAML	All
Patients, n	1044	433	569	498	470	149	3163
	filters to identify SNVs ≥10 sequencing reads in tumor and normal BAM file ≥3 alternative reads in tumor VCF file SNV alters/deletes uAUG or aTIS or deletes uStop codon ≥1 TV includes the SNV
All SNVs	7278	8756	8161	2017	26051	1913	48491
Affected patients, %	99.8	99.1	100	99.6	100	100	99.7
	additional filters to identify somatic SNVs ≥4 x higher alt/ref read ratio in tumor ≥2 patients with same somatic mutation
Recurrent somatic SNVs	1029	339	494	114	3748	258	5277
Affected patients, %	68.0	67.4	68.0	38.8	86.8	75.2	66.5
Variants in ≥1% of pts.	94	37	75	14	241	258	567
Affected patients, %	35.1	40.4	31.1	20.9	61.7	75.2	38.7
SNVs w/o dbSNP entry	80	45	56	3	2112	72	2363
% of recurrent som. SNVs	7.5	13.3	11.3	2.6	56.4	27.9	44.8