Table 3.
Summary of recent studies on loading osteogenic miRNAs into exosomes in vivo.
| Donor Cell | Recipient Model | Rout | Dose Exosome | miRNA/mRNA | Target Gene | Effect | Ref. |
|---|---|---|---|---|---|---|---|
| BMSCs | C57BL/6J mice | Intravenous injection | 100 µg protein | miR-29a | VASH1, COL1A1, VEGFA, RUNX1T1 | Increase osteogenesis Increase angiogenesis |
[96] |
| BMSCs | Sprague–Dawley (SD) rats | Intravenous injection | 200 µg protein | miR-128-3p | Runx2 | Increase osteogenesis | [97] |
| BMSCs | Sprague–Dawley (SD) rats | Intravenous injection | 100 µg protein | miR-150-3p | Runx2, Osterix, ALP and osteocalcin | Increase osteogenic differentiation | [98] |
| BMSCs | Balb/c mice | Intravenous injection | 200 µg protein | antagomir-188 | RUNX2, osterix (Sp7), osteocalcin (Bglap) | Increase osteogenic differentiation, Decrease adipogenic differentiation | [99] |
| BMSCs | Sprague–Dawley (SD) rats | Intravenous injection | 100 µg protein | miR-935 | STAT1 | Increase osteogenic differentiation | [100] |
| GMSCs | Wistar rats | 3D printing | 0.5 µg/µL | miR-2861,210 | VEGFA, RUNX2 COL1A1 | Increase osteogenesis Increase angiogenesis |
[95] |