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. 2021 Jun 8;22(12):6174. doi: 10.3390/ijms22126174

Figure 6.

Figure 6

Representative microphotographs of immunohistochemical staining of phospho-nucleophosmin (Thr199) in colonic adenocarcinomas differing in BRAF mutational status. (a) Upper part of the picture showing normal colonic crypts, with moderate nuclear staining. Below is colonic adenocarcinoma with BRAF mutation showing strong nuclear and cytoplasmic staining; (b) upper part of the picture showing normal colonic crypts, with moderate nuclear staining. Below is colonic adenocarcinoma with KRAS mutation showing weak nuclear and negative cytoplasmic staining; (c) upper part of the picture showing normal colonic crypts, with moderate nuclear staining. Below is colonic adenocarcinoma BRAF and KRAS wild types showing moderate nuclear and negative cytoplasmic staining. Magnification 100× (6a) and 200× (6b and 6c).