Table 2.
List of differentially down-regulated proteins with statistical significance (p < 0.05) in BRAFV600E mutant HT-29 cells in comparison to Caco-2 and SW480 colon cancer cells.
| Spot Number | Accession ID | Protein Name p-Value (HT-29 vs. Caco-2; HT-29 vs. SW480) |
Molecular Weight (kDa) | Peptide Matches | Sequence Coverage (%) |
SCORE |
|---|---|---|---|---|---|---|
| 183 | MOES_HUMAN | Moesin (0.001; 0.005) |
67.80 | 3 | 3.50 | 119.80 |
| 631 | K1C19_HUMAN | Keratin, type I cytoskeletal 19 (<0.0001; <0.0001) |
44.10 | 2 | 7.80 | 142.88 |
| 643 | K1C19_HUMAN | Keratin, type I cytoskeletal 19 (<0.0001; <0.0001) |
44.10 | 9 | 27.30 | 527.99 |
| 632 | K1C19_HUMAN | Keratin, type I cytoskeletal 19 (<0.0001; <0.0001) |
44.10 | 11 | 36.00 | 856.99 |
| 840 | ANXA3_HUMAN | Annexin A3 (0.0001; 0.0002) |
36.40 | 2 | 13.90 | 149.55 |
| 1048 | PCNA_HUMAN | Proliferating cell nuclear antigen (0.016; 0.002) |
29.09 | 13 | 59.00 | 97.00 |
| 1171 | MIXTURE 1 DBNL_HUMAN TBA1B_HUMAN |
Drebrin-like protein Tubulin alpha-1B chain (0.034; 0.001) |
48.46 50.80 |
17 16 |
34.00 39.00 |
88.00 86.00 |
| 1209 | T191A_HUMAN | Transmembrane protein 191A (0.001; 0.014) |
18.06 | 4 | 33.00 | 30.00 |
| 1147 | EPHA6_HUMAN | Ephrin type-A receptor 6 (0.0772; <0.0001) |
117.901 | 8 | 13.00 | 40 |
| 794 | HSP7C_HUMAN | Heat shock cognate 71 kDa protein (0.026; 0.131) |
70.90 | 3 | 7.60 | 214.36 |