Table 3.
Pathway enrichment analysis of up-regulated proteins in BRAFV600E mutant HT-29 colon cancer cells using the Reactome Pathway Database.
| Pathway Identifier | Pathway Name | #Entities Found | #Entities Total | Entities p-Value | Entities FDR | Submitted Entities Found |
|---|---|---|---|---|---|---|
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2 | 12 | 1.44 × 10−4 | 0.009 | YWHAQ; YWHAZ |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B: Cdk1 complex | 2 | 13 | 1.69 × 10−4 | 0.009 | YWHAQ; YWHAZ |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2 | 15 | 2.25 × 10−4 | 0.009 | YWHAQ; YWHAZ |
| R-HSA-114452 | Activation of BH3-only proteins | 2 | 30 | 8.88 × 10−4 | 0.026 | YWHAQ; YWHAZ |
| R-HSA-390522 | Striated Muscle Contraction | 2 | 36 | 0.001 | 0.028 | TPM1 |
| R-HSA-445355 | Smooth Muscle Contraction | 2 | 39 | 0.001 | 0.028 | TPM1 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2 | 55 | 0.003 | 0.041 | YWHAQ; YWHAZ |
| R-HSA-5625740 | RHO GTPases activate PKNs | 2 | 63 | 0.004 | 0.046 | YWHAQ; YWHAZ |
| R-HSA-9614085 | FOXO-mediated transcription | 2 | 66 | 0.004 | 0.046 | YWHAQ; YWHAZ |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2 | 72 | 0.005 | 0.049 | YWHAQ; YWHAZ |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2 | 78 | 0.006 | 0.059 | YWHAQ; YWHAZ |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2 | 88 | 0.007 | 0.059 | YWHAQ; YWHAZ |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | 1 | 5 | 0.007 | 0.059 | NPM1 |
| R-HSA-1237112 | Methionine salvage pathway | 1 | 6 | 0.009 | 0.061 | ENOPH1 |
| R-HSA-977347 | Serine biosynthesis | 1 | 9 | 0.013 | 0.078 | PSPH |
| R-HSA-1640170 | Cell Cycle | 4 | 670 | 0.015 | 0.078 | NPM1; YWHAQ; CAPG; YWHAZ |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3 | 367 | 0.016 | 0.078 | NPM1; YWHAQ; YWHAZ |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1 | 11 | 0.016 | 0.078 | CAPG |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1 | 11 | 0.016 | 0.078 | YWHAZ |
| R-HSA-69481 | G2/M Checkpoints | 2 | 151 | 0.020 | 0.078 | YWHAQ; YWHAZ |
| R-HSA-392517 | Rap1 signaling | 1 | 16 | 0.023 | 0.078 | YWHAZ |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1 | 17 | 0.025 | 0.078 | YWHAZ |
| R-HSA-109581 | Apoptosis | 2 | 182 | 0.029 | 0.078 | YWHAQ; YWHAZ |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 1 | 21 | 0.030 | 0.078 | NPM1 |
| R-HSA-397014 | Muscle contraction | 2 | 196 | 0.033 | 0.078 | TPM1 |
| R-HSA-166208 | mTORC1-mediated signaling | 1 | 24 | 0.035 | 0.078 | EIF4E |
| R-HSA-429947 | Deadenylation of mRNA | 1 | 25 | 0.036 | 0.078 | EIF4E |
| R-HSA-3214842 | HDMs demethylate histones | 1 | 26 | 0.037 | 0.078 | ARID5B |
| R-HSA-5357801 | Programmed Cell Death | 2 | 217 | 0.040 | 0.078 | YWHAQ; YWHAZ |
| R-HSA-1614635 | Sulfur amino acid metabolism | 1 | 28 | 0.040 | 0.078 | ENOPH1 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1 | 30 | 0.043 | 0.078 | UCHL3 |
| R-HSA-8949613 | Cristae formation | 1 | 31 | 0.045 | 0.078 | IMMT |
| R-HSA-9013424 | RHOV GTPase cycle | 1 | 33 | 0.047 | 0.078 | TPM1 |