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. 2021 Jun 5;11(6):1683. doi: 10.3390/ani11061683

Table 1.

Characteristics of studies excluded.

Study Type of Intervention Criteria
Bacha and Regassa, 2010 [32] UL Pregnancy rate only from cows with endometritis diagnosed by cytology
Baranski et al., (a) 2012 [33] and (b) 2013 [34] CB (a) Established threshold values for diagnosis of subclinical endometritis. (b) Determined the impact of cytological endometritis on pregnancy rates
Barlund et al., 2008 [7] CB, UL Compared thresholds of different techniques for diagnosis of endometritis
Barrio et al., 2015 [35] CB Diagnosed subclinical endometritis by Cytobrush and determined the impact on reproductive performance
Bicalho et al., 2016 [36] EB Pregnancy rate not mentioned
Binelli et al., 2015 [37] EB Transcriptome uterine analysis was retrospectively performed in pregnant and non-pregnant cows
Bolzenius et al., 2016 [38] EB Pregnancy rate not compared with non-biopsied cows
Brodzki et al., (a) 2015 [39], (b) 2014 [40], (a) UL, CB, (b) CB (a) Pregnancy rate not described. (b) Pregnancy rates were related to presence/absence of subclinical endometritis
Carneiro et al., (a) 2013 [41], (b) 2014 [42] (a)UL, (b) CB (a) Evaluate the cytological endometritis diagnosed by uterine lavage in reproductive performance. (b)Evaluate reproductive performance in cows diagnosed with subclinical endometritis
Chapwanya et al., 2009 [43]; 2010 [15]; 2012 [44] EB No control group. Same data in three studies
Cheong et al., (a) 2011 [45], (b) 2012 [46] UL (a) Determine risk factors for subclinical endometritis and its effect on reproductive performance. (b) Determine the use of leukocyte esterase strip as indicator of endometritis
Couto et al., 2013 [47] CB, UL Used uterine fluid to measure leukocyte esterase activity to diagnose endometritis
de Biase et al., 2018 [48] EB Diagnosis of infectious agents using EB but pregnancy rate was not reported
de Boer et al., 2015 [49] CB Assessed % PMN cells and PR given on cows with endometritis
De Sa et al., 2017 [50] EB Assess transcriptome analysis of endometrium on day 6 from pregnant and non-pregnant cows
Denis-Robichaud, 2015 [51] CB Used the leukocyte esterase test for diagnosis of endometrial health and as predictor of pregnancy status in cows with endometritis
Gabai et al., 2019 [52] CB and UL Pregnancy rate not described
Kasimanickam et al., (a) 2004 [12], (b) 2006 [53] (a) CB (b) None (a) Validated cytology for diagnosis of endometritis (b) They did not use any endometrial sampling procedure
Katagiri et al., 2006 [54] EB Pregnancy rate given but no control group
Lopez et al., 2012 [2] CB Pregnancy rate associated with endometrial health postpartum
Machado et al., 2012 [55] UL Pregnancy rate associated with endometrial health
Madoz et al., 2013 [56] CB Used endometrial cells to establish cut off values for endometritis in grazing cows
McDougall et al., 2011 [57] CB Pregnancy rate correlated with % PMN
Nehru et al., 2019 [58] CB and UL Pregnancy rate reported but no control group
Pascottini et al., 2015 [13] CB, CT Pregnancy rate not described
Pascottini et al., 2016 [59] CT Pregnancy rate not reported in non-sampled heifers
Pascottini et al., 2017 [60] CT Pregnancy rate not reported in non-sampled cows
Plontzke et al., 2010 [9] CB Pregnancy rates associated with % PMN in subclinical endometritis
Prunner et al., 2014 [61] CB Pregnancy rate determined by postpartum uterine health
Rhoads et al., 2008 [24] EB Pregnancy rate not reported
Ricci et al., 2015 [62] UL Pregnancy rate associated with %PMN in subclinical endometritis
Salasel et al., 2010 [63] UL Pregnancy rate associated with subclinical endometritis and risk factors
Santos et al., 2009 [64] UL Pregnancy rates associated with % PMN in Bos indicus cows
Scolari et al., 2017 [65] EB Assess transcriptome analysis of endometrium on day 6 from pregnant and non-pregnant cows
Senosy et al., 2012; [66] CB Fertility rates based on uterine health diagnosed postpartum
Sens and Heuwieser, 2013 [67] CB No control group
Studer et al., 1978 [6] EB Pregnancy rate is not mentioned after procedure
Van Schyndel et al., 2019 [68] CB, UL Compared cytologies for diagnosis of subclinical endometritis, but pregnancy rate is not described
Werner et al., 2012 [69] CB Pregnancy rate is not mentioned after procedure
Westerman et al., 2010 [3] CB Pregnancy rate is not mentioned after procedure
Zaayer et al., 1986 [70] EB Pregnancy rate is not mentioned after procedure

UL: uterine lavage; CB: cytobrush; EB: endometrial biopsy; CT: cytotape; PMN: polymorphonuclear cells; PR: pregnancy rate; SCE: subclinical endometritis.