Table 1.
Studies conducted in a European cohort.
| Study Type | Publication Year | Sample Size | Male/Female | Cohort Age Mean (SD) | Traits | Criteria for Discovery c | N° of Variants d (Discovery Stage) | Criteria for Replication e | N° of Variants f (Replication Stage) | N° of Sexual Dimorphism Variants | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GWAS | 2009 | 140,644 (Dis a: 38,580 European; Rep b: 102,064 European) | NA | 55.73 (9.67) | WC | WC/WHR, p < 1 × 10−5 BMI p > 0.01, Height p > 0.005 |
26 | p < 5 × 10−8 | 2 | NA | [67] |
| WHR | 1 | NA | |||||||||
| Meta-analysis GWAS | 2010 | 190,803 (Dis a: 77,167 European; Rep b: 113,636 European) | 82,483/108,979 | NA | WHR | p < 1.4 × 10−6 | 16 | p < 5 × 10−8 | 14 | 7 | [19] |
| Meta-analysis GWAS | 2015 | 210,088 (Dis a: 142,762 European; Rep b: 67,326 European) | 95,379/114,709 | 50 (10.3) | WHRadjBMI | NA | NA | p < 5 × 10−8 | 49 | 20 | [20] |
| Meta-analysis GWAS | 2015 | 320,485 Europeans | 51,625/60,654 | <=50 | WHRadjBMI | p < 1 × 10−5 | NA | p < 5 × 10−8 | 44 | 44 | [21] |
| 90,988/106,622 | >50 | ||||||||||
| Meta-analysis GWAS | 2018 | 663,598 Europeans | 206,951/245,351 * | 57 (8) * | WHR | p < 5 × 10−8 | 202 | NA | NA | NA | [23] |
| 660,648 Europeans | WHRadjBMI | p < 5 × 10−8 | |||||||||
| Meta-analysis GWAS | 2019 | 694,649 Europeans | NA | NA | WHRadjBMI | p < 5 × 10−9 | 346 | NA | NA | 105 | [24] |
| GWAS | 2017 | 239,856 Europeans (Dia a: 33,811, Rep b: 206,045) | 123,766/116,090 | 51.4 | WHRadjBMI | p < 1 × 10−5 | 85 | p < 5 × 10−8 | 1 | 3 | [69] |
| 54,693 Europeans (Dia a: 34,088, Rep b: 206,053) | 28,276/26,417 | 51.4 | WHR | 80 | 1 | 0 | |||||
| 67,767 Europeans (Dia a: 47,095, Rep b: 206,723) | 34,494/33,273 | 52 | WCadjBMI | 139 | 7 | 3 | |||||
| 68,267 Europeans (Dia a: 47,593, Rep b: 20,6737) | 33,792/34,475 | 50.1 | WC | 118 | 12 | 5 | |||||
| 54,595 Europeans (Dia a: 34,004, Rep b: 205,909) | 28,008/26,587 | 51.4 | HIP | 114 | 7 | 2 |
NA: Not applicable. * This study participants included two parts: Ukbiobank and GIANT—the radio of sex and age only showed in Ukbiobank participants; a Discovery stage sample; b Replication stage sample; c Criteria for discovery stage; d Number of variants found in the discovery stage by c criteria; e Criteria for replication in Asian study (also as a criterion for other types of studies); f Number of variants found in the replication stage by e criteria.