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. 2021 May 30;13(6):814. doi: 10.3390/pharmaceutics13060814

Table 1.

The characterization of the materials studied in this work.

Materials Yield (%) ρb (g/mL) ρt (g/mL) CI HR AR (°) d (0.5) (μm) Span Uniformity SA-BET (m2/g) SA-BJH (m2/g) PV (cm3/g) PD (nm)
Lactose 0.458 ± 0.007 0.864 ± 0.004 47.0 ± 1.0 1.89 ± 0.04 56.7 ± 0.7 42.5 ± 0.5 2.69 ± 0.07 0.927 ± 0.202 1.11 ± 0.02 1.25 0.00133 42.5
Lactose-0 69.0 0.329 ± 0.003 0.558 ± 0.005 41.0 ± 0.0 1.70 ± 0.00 45.3 ± 1.7 45.9 ± 0.2 3.40 ± 0.03 1.010 ± 0.011 3.44 ± 0.01 3.62 0.00447 49.4
Lactose-P1 85.3 0.398 ± 0.008 0.583 ± 0.007 31.7 ± 1.5 1.46 ± 0.03 42.2 ± 1.4 30.3 ± 0.1 2.21 ± 0.02 0.710 ± 0.012 1.58 ± 0.28 2.11 0.03010 570.0
Lactose-P2 85.5 0.397 ± 0.003 0.557 ± 0.011 28.7 ± 1.2 1.40 ± 0.02 40.5 ± 0.8 34.8 ± 0.1 2.11 ± 0.01 0.657 ± 0.007 1.56 ± 0.43 2.12 0.01720 323.0
Lactose-P3 89.1 0.376 ± 0.004 0.555 ± 0.007 32.3 ± 0.6 1.48 ± 0.01 40.0 ± 1.3 27.1 ± 0.1 2.04 ± 0.00 0.615 ± 0.002 2.03 ± 0.29 2.94 0.01870 254.0

Lactose, the raw material; P, polyvinylpyrrolidone (PVP K30); Lactose-0, processed without PVP K30; Lactose-P1, processed with 1% PVP K30; Lactose-P2, processed with 2% PVP K30; Lactose-P3, processed with 3% PVP K30; ρb, bulk density; ρt, tapped density; CI, Carr’s index; HR, Hausner ratio; AR, angle of repose; d (0.5), median particle size; span, particle size distribution; SA-BET, the surface area characterized by BET; SA-BJH, the surface area characterized by BJH; PV, BJH. Adsorption cumulative volume of pores between 17.000 nm and 3000.000 nm diameter; PD, BJH Adsorption average pore diameter.