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. 2021 Jun 1;11(6):827. doi: 10.3390/biom11060827

Figure 5.

Figure 5

Schematic showing the three interface regions (N, variable (V), and C) of TCF7L2. The schematics show the conformational preferences of TCF7L2 (red) in complex with β-catenin (cyan) in the different crystal structures. (A–C) are based on the crystal structures of Poy et al. (PDB 1JPW, [22]), Graham et al. (1JDH, [20]), and Sampietro et al. (2GL7, [25]), respectively. The N-terminal binding domain (N) and the C-terminal binding domain (C) each adopt very similar conformations in all three structures, but the variable region (V) had a different conformation in each structure.