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. 2021 May 31;13(6):817. doi: 10.3390/pharmaceutics13060817

Figure 4.

Figure 4

In vivo structure–activity relationship study. (a) The expression levels of miRNA-122-targeted or non-targeted mRNAs in the liver of mice (6-week-old male C57Bl6/J, n = 4), 7 days after a single injection of each construct at a dosage of 12.5 nmol/kg. (b,c) Their corresponding serum cholesterol levels and liver transaminase levels, respectively. ** p < 0.01 and * p < 0.05 (vs. saline).