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. 2021 May 29;11(6):807. doi: 10.3390/biom11060807

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Homology model of A. stephensi PanK with bound PZ-2891. Interactions between PZ-2891 and A. stephensi PanK predict that the mosquito protein is regulated by the same allosteric mechanism described for PZ-2891 regulation of human PanKs. PZ-2891 interacts with both protomers through hydrophobic interactions, hydrogen bond contacts, and π-π stacking interactions. Sequence numbering is assigned to A. stephensi PanK. The two A. stephensi PanK protomers are colored green and orange and PZ-2891 is yellow.