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. 2021 May 29;11(6):807. doi: 10.3390/biom11060807

Figure 4.

Figure 4

Oral provisioning of PZ-2891 increased and compound 7 decreased A. stephensi midgut CoA levels, respectively. (A). Mosquitoes provisioned with PZ-2891 had significantly increased levels of midgut CoA at 6 h (13 nM and 1.3 nM) and 24 h (13 nM) relative to DMSO control, with a pattern of greater increases in midgut CoA for 13 nM vs. 1.3 nM PZ-2891 at 6 h and 24 h. Differences between treatments and controls were evaluated using Student’s t-test. ** p < 0.01 and * p < 0.05. Three distinct biological cohorts of mosquitoes were assayed. (B). Mosquitoes provisioned with 620 nM and 62 nM compound 7 had reduced levels of midgut CoA at 24 h and 2 h, respectively, relative to DMSO control. Five distinct biological cohorts of mosquitoes were assayed. Differences between treatments and DMSO controls were evaluated using Student’s t-test. ** p < 0.01 and * p < 0.05. Five distinct biological cohorts of mosquitoes were assayed.