Table 2.
Studies using a combined antioxidants strategy.
| Study | Design | Study Population | Study Size | Dosage | Duration |
|---|---|---|---|---|---|
| Rodrigo et al., 2008 [27] | Randomized, double-blind placebo controlled | Essential hypertension | 110 | vitamin C (1 g/day) vitamin E (400 IU/day) |
8 weeks |
| Castillo et al., 2010 [174] | Randomized, double-blind placebo controlled | Open heart surgery | 95 | n-3 PUFA 2 g/d (EPA/DHA = 1:2) vitamin C (1 g/day) vitamin E (400 IU/day) | PUFA: 7 days before surgery until discharge Vitamin C and E: 2 days before surgery until discharge |
| Rodrigo et al., 2012 [175] | Randomized, double-blind placebo controlled | Open heart surgery | 152 | n-3 PUFA 2 g/d (EPA/DHA = 1:2) vitamin C (1 g/day) vitamin E (400 IU/day) | PUFA: 7 days before surgery until discharge Vitamin C and E: 2 days before surgery until discharge |
| Rodrigo et al., 2013 [176] | Randomized, double-blind placebo controlled | Open heart surgery | 203 | n-3 PUFA 2 g/d (EPA/DHA = 1:2) vitamin C (1 g/day) vitamin E (400 IU/day) | PUFA: 7 days before surgery until discharge Vitamin C and E: 2 days before surgery until discharge |
n-3 PUFA, omega-3 polyunsaturated fatty acids; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid.