Figure 4.

SD-OCT-ONH cross-sectional comparison and mean values for different treatment groups. (A,C): en face views of the optic disk in A) naïve (uninduced) and C) induced vehicle--treated eye. The uninduced eye in A shows a small, dark optic disk (ON), while the induced eye in C has a swollen, edematous disk (ON). (B,D): Cross-sectional views of the same optic disks seen in A and C, respectively. B. The uninduced eye has a relatively narrow ONH cross-sectional diameter (287 um) as measured between the two edges of the inner nuclear layer (INL) (shown as white arrows in B) in this particular slice. D. The induced eye in shows ONH edema with expansion of the INL–INL distance. Mean ONH diameter is defined as the mean of the three slices with the largest INL–INL distance. (E): Mean ONH diameters of naïve (white bar), vehicle (black bar), KML29 alone (MAGL inhibitor) (cross-hatched bar), PGJ₂ and KML29 combination (light speckle), and PGJ₂ and meloxicam (Melox) combination. There is a significant expansion of the mean ONH diameter following induction (331.3 ± 8.7 um naïve (n = 11) vs. 550.5 ± 22.3 um vehicle (n = 11) (sem); (***; significant > p < 0.001) p = 0.0002; Mann–Whitney two-tailed test). Comparisons between all induced groups were nonsignificant (NS) (p > 0.05).