Table 2.
Description of patients receiving GFD (n = 116): comparison of patients in terms of their response to the diet.
| Total (n = 116) |
Response (n = 72) |
Non-Response (n = 44) |
p Value | |
|---|---|---|---|---|
| Type of FBD symptoms: | ||||
| -IBS-D or functional diarrhoea -Functional bloating |
68 (58.6%) 48 (41.4%) |
39 (54.2%) 33 (45.8%) |
29 (65.9%) 15 (34.1%) |
0.21 |
| Age (mean ± SEM) | 42.4 ± 1.24 | 41.7 ± 1.6 | 43.7 ± 2 | 0.44 |
| Sex (% female) | 90 (77.6%) | 55 (76.4%) | 35 (79.5%) | 0.69 |
| Coeliac genetics: | ||||
| -HLA-DQ2.5 -HLA-DQ8 -HLA-DQ2.2 -1 allele DQ2.5 -Negative |
59 (51.8%) 32 (27.6%) 11 (5%) 7 (3.2%) 7 (3.2%) |
37 (52.9%) 22 (30.5) 6 (8.3%) 2 (2.8%) 5 (6.9%) |
22 (50%) 10 (22.7%) 5 (11.3%) 5 (11.3%) 2 (4.5%) |
0.77 |
| Serology: | ||||
| -Detectable anti-tTG2 titers (EmA neg) | 3 (2.6%) | 2 (2.8%) | 1 (2.3%) | 0.87 |
| Histology (IEL count): | ||||
| >25% 19–25% <19% |
63 (54.8%) 18 (15.7%) 35 (30.2%) |
41 (56.9%) 11 (15.3%) 19 (26.4%) |
22 (50%) 7 (15.9%) 15 (34.1%) |
0.67 |
| Coeliac IEL cytometry pattern: | ||||
| -Non-coeliac -Isolated increase in TCRγδ+ cells -Coeliac lymphogram |
64 (55.2%) 20 (17.2%) 32 (27.6%) |
34 (47.2%) 11 (15.3%) 27 (37.5%) |
30 (68.2%) 9 (20.5) 5 (11.4%) |
0.019 |
| Low-grade coeliac score > 10 | 28 (24.1%) | 23 (31.9%) | 5 (11.4%) | 0.027 |
| Score > 10 and coeliac lymphogram | 21 (18.1%) | 18 (25%) | 3 (6.8%) | 0.023 |
| Score > 10 and isolated increase in TCRγδ+ cells | 7 (6.0%) | 5 (6.9%) | 2 (4.5%) | 0.71 |
FBD: functional bowel disease; anti-tTG2: IgA anti-transglutaminase antibodies; EmA: IgA anti-endomysium antibodies; IEL: intraepithelial lymphocytes.