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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: FASEB J. 2021 Jun;35(6):e21618. doi: 10.1096/fj.202100049R

Figure 2: Prolonged and repeated depletion of macrophages results in adverse systemic effects.

Figure 2:

(A) Schematic showing twice a week dosing regimen of AP20187 after postnatal day P5 Achilles tendon injury. (B) AP20187-treated mice were smaller and showed abnormal swelling of tarsal regions at D13 post-injury (red arrows) with (C) impaired weight gain (n=3–5). (D) Schematic showing once a week dosing regimen of AP20187 after postnatal day P5 Achilles tendon injury. (E) AP20187-treated mice also developed abnormal swelling of tarsal regions at D56 post-injury (red arrows) and (F) impaired weight gain at later timepoints (n=3–5). Data reported as mean±stdev and analyzed by 2-way ANOVA with Tukey’s post-hoc test. ** p<0.01; *** p<0.001 **** p<0.0001.