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Three-dimensional structural analysis of A/H1N1 HA protein (A). Top view of head domain of H1N1 showing antigenic sites located in different regions of the HA molecule (B). Superimposed HA structures of A/Michigan/45/2015 (H1N1) and A/H1N1 Thai isolates, where mutations at antigenic sites are highlighted in blue, magenta, and red. HA structures were built based on the structure of A/California/07/2009(H1N1) HA protein, PDB ID: 3UBE.
