Table 1.
Characteristics of ROS/MAP Dataset. Cerebral atherosclerosis was rated as none (0), mild (1), moderate (2), or severe (3). Education is the number of years of regular education at baseline. Post-mortem interval is time in hours between death to autopsy. Vascular risk factors is a composite measure of vascular risk comprising measures of hypertension, diabetes, and smoking history. Tangle density is average tangle density per mm2 over sampled cortical brain regions. Amyloid is average percent area occupied by amyloid β over sampled cortical brain regions.
| Characteristic | N | Percent | |
|---|---|---|---|
| Sex | |||
| Female Male |
877 448 |
66.2 33.8 |
|
| Cognitive diagnosis at death * Normal cognition Mild cognitive impairment Alzheimer’s dementia Other dementia |
397 297 522 23 |
30.0 22.4 39.4 1.7 |
|
| Mean (SD) | Median | Range | |
| Age at enrollment | 80.4 (6.91) | 80.8 | 63.0–102.2 |
| Age at death | 89.5 (6.56) | 89.8 | 66.0–108.3 |
| Education (years) | 16.4 (3.60) | 16.0 | 5.0–30.0 |
| Post-mortem interval (hours) | 9.1 (8.01) | 6.6 | 0.0–98.3 |
| Vascular risk factors | 1.1 (0.84) | 1.0 | 0.0–3.0 |
| N | Percent | ||
| Gross infarct (Present) | 585 | 44.2 | |
| Microinfarct (Present) | 499 | 37.7 | |
| Mean (SD) | Median | Range | |
| Cerebral atherosclerosis | 1.25 (0.81) | 1.00 | 0.0–3.0 |
| Alzheimer’s disease pathology | |||
| Amyloid | 4.1 (4.07) | 3.1 | 0.0–22.9 |
| Tangles | 7.3 (8.79) | 4.3 | 0.0–78.5 |
For quantitative variables, the mean, standard deviation (SD), median, and range are presented. For gross infarct and microinfarct, the number of participants with data (N) and the percent of participants with infarcts is presented. * Cognitive diagnosis was unavailable for 86 (6.49%) of the subjects.