Table A2.
Summary of demographic and neuropathologic characteristics per cohort. Values are presented for the ROS/MAP, Banner, and ADGC samples (altogether and split by genotyping wave, or batch) included in the current analysis. Cerebral atherosclerosis semiquantitive scores range from 0 (none) to 3 (severe). Braak stage ranges from 0 to 6.
| Banner | ROS/MAP | ADGC (All Waves) | ADGC Wave 1 | ADGC Wave 2 | ADGC Wave 3 | ADGC Wave 4 | ADGC Wave 5 | ADGC Wave 6 | ADGC Wave 7 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample Count | 154 | 1325 | 1914 | 146 | 277 | 308 | 297 | 344 | 338 | 204 | |
| Age (years) | median | 86 | 90 | 85 | 85 | 85 | 86 | 85 | 86 | 84 | 84 |
| mean | 85.5 | 89.5 | 83.7 | 84.8 | 84.8 | 84.4 | 83.4 | 84.5 | 81.4 | 83.3 | |
| SD | 7.11 | 6.56 | 9.73 | 8.75 | 7.05 | 10.41 | 10.05 | 9.20 | 12.17 | 7.42 | |
| range | 66–103 | 66–108 | 47–111 | 57–105 | 65–98 | 55–111 | 47–103 | 56–102 | 52–109 | 67–102 | |
| Sex | N female | 66 | 877 | 916 | 72 | 135 | 141 | 133 | 175 | 169 | 91 |
| N male | 88 | 448 | 998 | 74 | 142 | 167 | 164 | 169 | 169 | 113 | |
| % female | 43% | 66% | 48% | 49% | 49% | 46% | 45% | 51% | 50% | 45% | |
| % male | 57% | 34% | 52% | 51% | 51% | 54% | 55% | 49% | 50% | 55% | |
| Cerebral Atherosclerosis | median | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 |
| mean | 1.87 | 1.25 | 1.41 | 1.38 | 1.66 | 1.47 | 1.31 | 1.38 | 1.31 | 1.33 | |
| SD | 0.96 | 0.81 | 0.92 | 0.91 | 0.90 | 0.87 | 0.93 | 0.89 | 0.90 | 1.02 | |
| Cognitive Diagnosis at Death | % Normal | 40% | 30% | 16% | 38% | 5% | 14% | 13% | 21% | 12% | 16% |
| % MCI | 16% | 22% | 11% | 12% | 3% | 7% | 16% | 13% | 15% | 5% | |
| % AD | 44% | 39% | 47% | 33% | 72% | 59% | 44% | 36% | 46% | 32% | |
| % Other Dementia | 0% | 2% | 26% | 18% | 20% | 20% | 26% | 29% | 26% | 47% | |
| PMI (hours) | median | 3.0 | 6.6 | 9.0 | 8.3 | 7.0 | 9.2 | 10.6 | 9.7 | 10.0 | 7.9 |
| mean | 3.0 | 9.1 | 13.5 | 11.7 | 11.8 | 13.6 | 14.2 | 14.6 | 14.3 | 12.2 | |
| SD | 0.8 | 8.0 | 13.8 | 9.2 | 12.7 | 13.1 | 13.5 | 14.9 | 14.0 | 14.5 | |
| range | 1.5–5.5 | 0.0–98.3 | 0.0–99.0 | 0.5–37.5 | 1.3–81.8 | 0.0–63.7 | 0.0–72.0 | 1.3–96.0 | 0.0–96.0 | 0.0–99.0 | |
| N missing | 0 | 0 | 1112 | 107 | 194 | 220 | 205 | 210 | 133 | 43 | |
| Gross Infarct * | % present | 44% | 44% | 20% | 25% | 22% | 18% | 20% | 20% | 19% | 16% |
| N missing | 0 | 0 | 4 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | |
| Microinfarct * | % present | − | 38% | 24% | 27% | 22% | 23% | 19% | 22% | 28% | 27% |
| N missing | − | 0 | 3 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | |
| Braak Stage | median | 4 | 4 | 5 | 4 | 5 | 5 | 5 | 4 | 5 | 5 |
| mean | 4.0 | 3.6 | 4.4 | 3.8 | 4.8 | 4.5 | 4.5 | 3.8 | 4.6 | 4.6 | |
| SD | 1.3 | 1.2 | 1.7 | 1.7 | 1.5 | 1.7 | 1.6 | 1.8 | 1.6 | 1.7 | |
| N missing | 0 | 0 | 3 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | |
| CERAD Neuritic Plaque Density | none | 21% | − | 17% | 27% | 10% | 16% | 15% | 20% | 16% | 17% |
| sparse | 8% | − | 13% | 12% | 8% | 12% | 13% | 22% | 13% | 11% | |
| moderate | 18% | − | 22% | 20% | 16% | 23% | 26% | 26% | 19% | 21% | |
| frequent | 52% | − | 48% | 41% | 67% | 49% | 46% | 32% | 53% | 51% | |
| N missing | 3 | − | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | |
| CERAD confidence in AD | No AD | 24% | 23% | − | − | − | − | − | − | − | − |
| Possible AD | 25% | 9% | − | − | − | − | − | − | − | − | |
| Probable AD | 5% | 35% | − | − | − | − | − | − | − | − | |
| Definite AD | 40% | 33% | − | − | − | − | − | − | − | − | |
| N missing | 10 | 0 | − | − | − | − | − | − | − | − |
* The Banner infarct variable includes all infarct types.