Table 1.
The mean values and the age associations of the regional metabolite concentrations and the spectral linewidths estimated with linear regression analysis.
| Region | NAA | tCr | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N a | Mean b | SD b | R | p | Intercept b | Slope b | Variations c | N a | Mean b | SD b | R | p | Intercept b | Slope b | Variations c | ||
| Right caudate nucleus | 74 | 11.28 | 2.28 | −0.31 | 0.0072 | 13.53 ± 0.85 | −0.0523 ± 0.0189 | −5.2 | 74 | 10.82 | 1.83 | 0.02 | 0.8830 | ||||
| Left caudate nucleus | 76 | 11.40 | 2.21 | −0.29 | 0.0103 | 13.41 ± 0.80 | −0.0482 ± 0.0183 | −4.8 | 76 | 11.13 | 2.55 | −0.02 | 0.8378 | ||||
| Right putamen | 80 | 9.30 | 1.63 | −0.31 | 0.0050 | 10.87 ± 0.57 | −0.0367 ± 0.0127 | −3.7 | 80 | 9.01 | 1.25 | −0.12 | 0.2910 | ||||
| Left putamen | 80 | 9.22 | 1.40 | −0.52 | 0.0000 | 11.48 ± 0.44 | −0.0531 ± 0.0098 | −5.3 | 80 | 9.19 | 1.13 | −0.25 | 0.0254 | 10.07 ± 0.40 | −0.0205 ± 0.0090 | −2.0 | |
| Right pallidum | 75 | 8.41 | 1.91 | −0.16 | 0.1819 | 75 | 8.09 | 1.38 | −0.33 | 0.0044 | 9.45 ± 0.49 | −0.0322 ± 0.0110 | −3.2 | ||||
| Left pallidum | 77 | 8.33 | 2.11 | −0.24 | 0.0330 | 9.91 ± 0.76 | −0.0374 ± 0.0172 | −3.7 | 77 | 8.80 | 2.02 | −0.29 | 0.0102 | 10.61 ± 0.72 | −0.0428 ± 0.0162 | −4.3 | |
| Right thalamus | 80 | 8.82 | 1.17 | −0.16 | 0.1534 | 80 | 8.63 | 1.33 | 0.11 | 0.3333 | |||||||
| Left thalamus | 80 | 9.02 | 1.64 | −0.34 | 0.0022 | 10.73 ± 0.57 | −0.0400 ± 0.0127 | −4.0 | 80 | 8.63 | 1.30 | −0.04 | 0.7362 | ||||
| Region | Cho | Glu | Gln | ||||||||||||||
| N a | Mean b | SD b | R | p | N a | Mean b | SD b | R | p | N a | Mean b | SD b | R | p | |||
| Right caudate nucleus | 74 | 2.61 | 0.70 | 0.07 | 0.5784 | 72 | 7.20 | 3.16 | −0.07 | 0.5483 | 72 | 4.72 | 3.46 | 0.06 | 0.6276 | ||
| Left caudate nucleus | 75 | 2.77 | 0.66 | 0.00 | 0.9856 | 70 | 8.59 | 3.09 | 0.10 | 0.4282 | 73 | 3.69 | 3.12 | 0.08 | 0.5064 | ||
| Right putamen | 79 | 1.95 | 0.38 | 0.15 | 0.1905 | 75 | 7.15 | 2.07 | −0.20 | 0.0915 | 78 | 2.53 | 2.05 | −0.18 | 0.1113 | ||
| Left putamen | 80 | 1.93 | 0.41 | 0.02 | 0.8555 | 76 | 7.53 | 2.05 | −0.19 | 0.1076 | 77 | 3.08 | 2.07 | −0.19 | 0.0901 | ||
| Right pallidum | 75 | 1.76 | 0.50 | 0.13 | 0.2689 | 74 | 5.90 | 2.63 | −0.11 | 0.3585 | 71 | 3.64 | 2.59 | 0.08 | 0.5121 | ||
| Left pallidum | 77 | 1.71 | 0.53 | 0.00 | 0.9845 | 73 | 6.67 | 2.71 | −0.07 | 0.5825 | 76 | 3.46 | 3.00 | −0.21 | 0.0740 | ||
| Right thalamus | 80 | 2.11 | 0.45 | 0.06 | 0.6059 | 75 | 6.68 | 1.80 | −0.08 | 0.4979 | 76 | 2.72 | 1.83 | −0.11 | 0.3600 | ||
| Left thalamus | 80 | 2.09 | 0.46 | −0.02 | 0.8782 | 78 | 6.81 | 2.01 | −0.16 | 0.1613 | 76 | 2.79 | 1.89 | 0.04 | 0.7213 | ||
| Region | mI | Linewidth (Hz) | |||||||||||||||
| N a | Mean b | SD b | R | p | Intercept b | Slope b | Variations c | N a | Mean | SD | R | p | Intercept b | Slope b | Variations c | ||
| Right caudate nucleus | 74 | 3.95 | 2.00 | 0.26 | 0.0261 | 2.31 ± 0.76 | 0.0382 ± 0.0168 | 3.8 | 74 | 8.34 | 1.22 | 0.19 | 0.1119 | ||||
| Left caudate nucleus | 76 | 4.51 | 2.19 | 0.25 | 0.0283 | 2.80 ± 0.80 | 0.0410 ± 0.0184 | 4.1 | 76 | 8.72 | 1.05 | 0.17 | 0.1324 | ||||
| Right putamen | 78 | 3.24 | 1.15 | 0.14 | 0.2199 | 80 | 7.94 | 0.93 | 0.17 | 0.1287 | |||||||
| Left putamen | 75 | 3.36 | 1.16 | 0.11 | 0.3382 | 80 | 7.99 | 0.84 | 0.27 | 0.0142 | 7.28 ± 0.30 | 0.0166 ± 0.0066 | 1.7 | ||||
| Right pallidum | 74 | 3.39 | 1.56 | 0.00 | 0.9889 | 75 | 8.74 | 1.04 | 0.13 | 0.2482 | |||||||
| Left pallidum | 68 | 3.53 | 1.43 | −0.19 | 0.1160 | 77 | 9.13 | 1.08 | 0.02 | 0.8503 | |||||||
| Right thalamus | 77 | 3.60 | 1.02 | 0.25 | 0.0286 | 2.82 ± 0.37 | 0.0183 ± 0.0082 | 1.8 | 80 | 7.74 | 0.83 | 0.31 | 0.0054 | 6.96 ± 0.29 | 0.0185 ± 0.0065 | 1.8 | |
| Left thalamus | 77 | 3.53 | 1.25 | 0.12 | 0.3082 | 80 | 7.89 | 1.02 | 0.15 | 0.1920 | |||||||
an = number of sampled subjects. Values of several ROIs were not sampled for all subjects according to quality criteria; b in ratio to internal water and in institutional units for metabolites, intercept and slope are given as mean ± SE; c calculated in ratio to the values at age of 20 years and given in percentage per decade.