Skip to main content
. 2021 Jun 1;10(6):1122. doi: 10.3390/plants10061122

Figure 4.

Figure 4

G. procumbens increases the expression of genes involved in wound healing in human keratinocytes, fibroblasts, endothelial cells and mast cells cultured in diabetic conditions: (a) Primary human keratinocytes, (b) fibroblasts, (c) endothelial cells and (d) the human mast cell line LAD2 were pretreated with 38 mM glucose (high glucose) or 38 mM mannitol for 24 h and then stimulated with 100 μg/mL G. procumbens (GP) or 0.1% DMSO in normal medium (Veh: vehicle) or 0.1% DMSO in high-glucose medium (HG) for 48 h. mRNA expression of ANG, PDGF, VEGF and FGF was measured with real-time PCR. The values are presented as the mean ± SD of five independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001 for the comparisons between vehicle and G. procumbens (GP) in normal medium. & p < 0.05, && p < 0.01, &&& p < 0.001 and &&&& p < 0.0001 for the comparisons between vehicle (HG) and G. procumbens (HG+GP) in high-glucose medium. # p < 0.05, ## p < 0.01, ### p < 0.001 and #### p < 0.0001 for the comparisons between vehicle in normal medium and vehicle in high-glucose medium (HG).