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. 2021 Jun 1;10(6):1122. doi: 10.3390/plants10061122

Figure 7.

Figure 7

G. procumbens promotes the proliferation of human keratinocytes, fibroblasts and endothelial cells under diabetic conditions: (a) Primary human keratinocytes, (b) fibroblasts and (c) endothelial cells were pretreated with 38 mM glucose (high glucose) or 38 mM mannitol for 24 h and then stimulated with 50 μg/mL G. procumbens (GP) or 0.1% DMSO in normal medium (Veh: vehicle) or 0.1% DMSO in high-glucose medium (HG) for 48 h. Cell proliferation was assessed using a 5-bromo-2′-deoxyuridine (BrdU) Labeling and Detection Kit III. Values are presented as the mean ± SD of four independent experiments. **** p < 0.0001 for the comparison between vehicle and G. procumbens (GP) in normal medium. &&&& p < 0.0001 for the comparison between vehicle (HG) and G. procumbens (HG+GP) in high-glucose medium. # p < 0.05 for the comparison between vehicle in normal medium and vehicle in high-glucose medium (HG).