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Pathological features of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA) large duct type, and combined HCC-CCA. HCC shows a trabecular growth pattern, whereas large duct type iCCA shows a glandular structure with mucin production. Combined HCC-CCA shows both HCC and iCCA features. Keratin 19 staining shows diffuse and intense cytoplasmic positivity in iCCA, but negative in HCC. Combined HCC-CCA shows K19 weak expression in the cholangiocytic differentiated area.
