Table 5.

List of identified genes mediating both H₂O₂ and HOCl-resistance.

Gene	Known or Projected Functions
leuA	2-isopropylmalate synthase; involved in the first committed step in leucine biosynthesis [29].
prpE	Propionyl-CoA synthetase; catalyzes formation of propionyl-CoA via the methylcitrate cycle [31].
sucC	β subunit of succinyl-CoA synthetase [47].
ybhC	An outer membrane lipoprotein [34].
hyaA	Small subunit of hydrogenase-1; contains a unique proximal [4Fe-3S] cluster that is essential for oxygen tolerance [63].
ydeQ	Uncharacterized gene.
cheW	Chemotaxis protein; in the ternary receptor complexes of two-component signaling pathways [64].
motB	Motility protein B; comprises the stator element of the flagellar motor complex with MotA [53].
yodA	Metal-binding protein; may function as a periplasmic zinc chaperone delivering zinc to apo-enzymes in this compartment [65].
ydfB	Uncharacterized gene.
fliS	Flagellar biosynthesis protein; substrate-specific chaperones of the flagellar export system [66].
gloA	Glyoxalase I; catalyzes the first of two sequential steps in the conversion of methylglyoxal to D-lactate [67].
ydfD	A lysis protein encoded by the Qin prophage [68].
slyB	Outer membrane lipoprotein [69].
yoeE	TonB-dependent receptor plug domain-containing protein; may be regulated by Fur regulon [70].
sbmC	DNA gyrase inhibitor; protects cell from DNA damage cause by DNA-bound gyrase [71].
upp	Uracil phosphoribosyltransferase; a pyrimidine salvage enzyme that catalyzes the synthesis of uridine 5′-monophosphate from uracil and 5-phospho-α-D-ribose 1-diphosphate [72].
yhaJ	DNA-binding transcriptional activator; a member of the LysR protein family [73].
agaR	DNA-binding transcriptional repressor [74].
exbD	A component of the energy-transducing Ton system [56].
agaS	Putative galactosamine-6-phosphate deaminase/isomerase.
ilvA	Threonine deaminase; carries out the first step in the synthesis of isoleucine [41].
ubiD	3-octaprenyl-4-hydroxybenzoate decarboxylase; an enzyme of the ubiquinol-8 biosynthesis pathway that catalyzes the decarboxylation of 3-octaprenyl-4-hydroxybenzoate [75].