Figure 6.

Exosomes modulate the gene expressions of several structural proteins and enzymes involved in matrix remodeling and contractility. The graphs represent the relative mRNA levels of selected genes obtained via qPCR for dermal fibroblasts in normal conditions (control), fibroblasts differentiated towards a myofibroblast phenotype with TGFβ1, fibroblasts incubated with exosomes (Exo), and myofibroblasts exposed to exosomes. COL1A1—type I collagen, COL3A1—type III collagen, FN1—fibronectin, MMP—matrix metalloproteinase, TIMP—tissue inhibitor of metalloproteinase, EMMPRIN (BSG)—extracellular matrix metalloproteinase inducer, ACTA2—α-smooth muscle actin. Data are means ± SD (n = 3), * p < 0.05; ** p < 0.01, *** p < 0.001, ns—not significant.