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. 2021 Jun 9;22(12):6239. doi: 10.3390/ijms22126239

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Exosomes support wound healing on a human skin organotypic model. (A) Histological (hematoxylin and eosin staining) and immunofluorescence images showing the skin-like structure of the organotypic culture versus human adult skin tissue (left). Note the expression of keratinocytes markers fillagrin (FLG) and keratins (KRT) 5, 10, and 14, similar to the skin control. (B) Hematoxylin and eosin staining showing the healing of the skin organotypic cultures: left, image taken immediately after performing the punch wound (day 0 post-wound); right, after 3 days for the samples incubated with complete medium (positive control), basal medium (negative control), and exosomes (Exo).