Table 3.
Ratio of MICs of cyclized peptide versions over MICs of the linear peptide.
| Bacteria | Growth Media | Ratio c-optP7/optP7 | Ratio L6-optP7-Mco/optP7 |
|---|---|---|---|
| P. aeruginosa | MH | 47.3 | 20.6 |
| MH + 10% serum | NA | NA | |
| 1/5 MH | 11.3 | 10.0 | |
| 1/5 MH + 10% serum | 5.8 | 1.3 | |
| E. coli | MH | 88.8 | 77.5 |
| MH + 10% serum | NA | NA | |
| 1/5 MH | 10.0 | 3.3 | |
| 1/5 MH + 10% serum | 22.5 | 18.8 | |
| K. pneumoniae | MH | NA | 41.3 |
| MH + 10% serum | ND | ND | |
| 1/5 MH | 47.3 | 20.7 | |
| 1/5 MH + 10% serum | 5.9 | NA | |
| A. baumannii | MH | ND | 41.3 |
| MH + 10% serum | ND | ND | |
| 1/5 MH | 5 | 5 | |
| 1/5 MH + 10% serum | 23.7 | 10.3 | |
| VRE | BHI | NA | NA |
| BHI + 10% serum | ND | ND | |
| 1/5 BHI | 22.5 | 18.8 | |
| 1/5 BHI + 10% serum | NA | 2.6 | |
| MRSA | MH | 23.6 | ND |
| MH + 10% serum | NA | NA | |
| 1/5 MH | 18 | 8 | |
| 1/5 MH + 10% serum | NA | NA |
For an MIC range, the average was determined and used for calculating the ratio. Serum = human serum; ND = not determined; when calculation of ratio was not possible, it was labelled as NA = not applicable; MRSA = methicillin-resistant Staphylococcus aureus; VRE = vancomycin-resistant Enterococcus; MH = Mueller–Hinton broth; BHI = brain heart infusion broth.