Table 1.
General characteristics, urodynamic parameters, contractile responses, and count analysis of leukocytes for different experimental groups.
| Control | Ketamine | Ketamine+ Rapamycin |
Ketamine+ Wortmannin |
|
|---|---|---|---|---|
| No. rats | 10 | 10 | 10 | 10 |
| General characteristics | ||||
| Body weight (g) | 248.4 ± 38.2 | 231.7 ± 46.8 | 240.5 ± 23.8 | 237.5 ± 26.4 |
| Bladder weight (mg) | 141.3 ± 16.8 | 173.5 ± 18.7 * | 155.0 ± 10.3 # | 167.0 ± 14.9 * |
| Water intake (cc/24 h) | 30.3 ± 5.9 | 29.9 ± 6.4 | 35.8 ± 7.3 | 37.4 ± 7.1 |
| Urine output (cc/24 h) | 19.7 ± 5.6 | 20.7 ± 5.3 | 24.3 ± 5.8 | 22.9 ± 4.7 |
| Serum parameters | ||||
| Ketamine (ng/mL) | ND | ND | ND | ND |
| Norketamine (ng/mL) | ND | ND | ND | ND |
| Urine parameters | ||||
| Ketamine conc. (ng/mL) | ND | 1268.3 ± 231.5 ** | 1096.7 ± 175.8 ** | 1108.7 ± 195.4 ** |
| Norketamine conc. (ng/mL) | ND | 10150.2 ± 1146.8 ** | 8790.0 ± 1235.4 ** | 9690.0 ± 1033.7 ** |
Note: No., number; ND, not detected; Values are mean ± SD for n = 10. * p < 0.05; ** p < 0.01 vs. control (saline) group; # p < 0.05 vs. ketamine group.