Table 4.

Potential advantages and drawbacks of serological testing in recipients of COVID-19 vaccinations.

Advantages	Drawbacks
Assessment of baseline seroprevalence of SARS-CoV-2 infection in non-vaccinated individuals Identification of low- or non-responders to COVID-19 vaccinations Timely detection of the fast decay of anti-SARS-CoV-2 antibody levels	No equivalence to date between anti-SARS-CoV-2 antibody titer and vaccine efficiency No perfect equivalence between anti-SARS-CoV-2 antibody titer and neutralizing activity Cost-effectiveness of different testing strategies needs to be proven Enormous volume of blood drawings and increase of laboratory workload