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. 2021 May 27;10(6):642. doi: 10.3390/antibiotics10060642

Table 2.

In vitro models for plasmodicidal activity assays against human liver-stage malaria.

Cell type ECM Well Format Culture Drugs Biomarkers References
Primary human hepatocytes (PHHs) Type I collagen
(rat tail)		 96-well plates Coculture with murine embryonic fibroblasts

  • Primaquine

 Circumsporozoite protein (P.f.) [17]
384-well plate Monoculture

  • Compound library

  • Phosphatidylinositol 4-kinase inhibitor (KDU691)

  • Primaquine

  • Tafenoquine

  • Atovaquone

 GAPDH (P.f.)
UIS4 (P.v.)		 [18]
imHCs Matrigel 8-well plate Monoculture

  • Primaquine

 Plasmodium HSP70
UIS4 (P.v.)		 [21]
iPSC-derived hepatocytes No information No information Monoculture

  • Primaquine

 HSP70 (P.f.) [22]

P.f., P. falciparum; P.v., P. vivax.