Figure 2.

Effect of parthenolide (10 µM) on IFN-α 2a-mediated activation of NF-ĸB (A) or suppression of PXR (B) in LS180 cells after 6 h of exposure to 5000 U/mL of IFN-α 2a. Data shown are the mean ± S.E.M. of three independent experiments with technical quadruplets each. Statistical significance was evaluated using a nonparametric Kruskal–Wallis test and Dunn’s multiple comparison test. Single p values refer to comparison with untreated controls, whereas the p values above line show significance between treatments being connecting by this line. p values < 0.05 were considered significant.