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. 2021 Jun 10;12(6):895. doi: 10.3390/genes12060895

Figure 2.

Figure 2

(a) Confusion matrix for the cytogenetically defined (diagnostic-known) vs. DNA methylation predicted cytogenetic subtypes (N = 33). (b) Heatmap and hierarchical clustering of 127 samples taken at AML diagnosis or relapse from patients belonging to the four subtypes most common subtypes; t(8;21)/RUNX1-RUNX1T1, inv(16)/CBFB-MYH11, MLL/KMT2A-rearranged and NK. The methylation status of the selected 1300 CpG sites are plotted in the heatmap. The samples are in columns labeled by AML subtype, whether the sample was cytogenetically defined (true/diagnostic-known) or cytogenetically undefined (DNA methylation predicted), and if the sample was taken at AML diagnosis or relapse.