Table 1.
Cytogenetic subtype, age range, central nervous system (CNS) involvement, stem cell transplantation (SCT), and FAB classification for the 142 pediatric AML patient samples. The number of samples taken at AML diagnosis and relapse are presented. When known, the subtype of the relapse samples is indicated as the same subtype as their diagnostic pair.
| Cytogenetic Subtype | Normal Karyotype (NK) |
MLL/KMT2A Rearranged | Undefined | t(8;21) RUNX1/RUNX1T1 |
inv(16) CBFB/MYH11 |
mono 7 | t(15;17) PML-RARA |
sole +8 | 3q21q26 |
|---|---|---|---|---|---|---|---|---|---|
| Number of diagnostic Samples | 30 | 25 | 24 | 19 | 12 | 5 | 4 | 3 | 1 |
| Number of relapse samples | 8 | 1 | 5 | 4 | 1 | - | - | - | - |
| Age range | 1–18 | 0–16 | 0–17 | 2–16 | 1–17 | 1–5 | 3–16 | 3–14 | 14 |
| CNS involvement | - | - | - | - | - | - | - | - | - |
| Yes | 4 | 1 | 2 | 6 | - | - | - | - | - |
| No | 34 | 25 | 27 | 17 | 12 | 4 | 3 | 3 | 1 |
| Missing | - | - | - | - | 1 | 1 | 1 | - | - |
| SCT | - | - | - | - | - | - | - | - | - |
| Yes | 8 | 3 | 1 | - | - | 5 | - | 2 | - |
| No | 30 | 23 | 27 | 23 | 13 | - | 3 | 1 | 1 |
| Missing | - | - | 1 | - | - | - | 1 | - | - |
| FAB | - | - | - | - | - | - | - | - | - |
| M0 | 2 | - | - | 1 | - | 2 | - | 1 | - |
| M1 | 7 | - | 3 | 1 | - | 1 | - | 1 | 1 |
| M2 | 14 | 1 | 3 | 19 | 3 | 1 | - | - | - |
| M3 | 1 | - | 1 | - | - | - | 4 | - | - |
| M4 | 10 | 1 | 10 | 2 | 9 | - | - | - | - |
| M5 | - | 24 | 4 | - | - | 1 | - | 1 | - |
| M6 | 3 | - | 2 | - | - | - | - | - | - |
| M7 | - | - | 4 | - | - | - | - | - | - |
| Missing | 1 | - | 2 | - | 1 | - | - | - | - |