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Role of Cathepsin D in cancer and neurological disorders. Cathepsin D mutations may cause a decrease in its lysosomal traffic and activity, leading to protein aggregation in the organelles and neurodegenerative diseases development. Protein aggregation may cause lysosomal membrane permeabilization with the subsequent increase of cathepsin D outside the lysosomes. On the other hand, the excessive extracellular activity of cathepsin D can contribute to tumorigenesis.
