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. 2021 Jun 8;22(12):6171. doi: 10.3390/ijms22126171

Figure 2.

Figure 2

The effect of chronic administration of BSO and GBR 12909, alone or in combination, during postnatal days p5–p16 on cognitive functions assessed in adolescent (A–C) and adult (D) Sprague–Dawley rats. (A1–D1) The effects of the studied model compounds on the exploration of two identical objects in the acquisition trials (session T1). (A2–D2) The effects of the studied model compounds on the exploration of a novel and familiar object in the retention trial (Session T2). (A3–D3) The effects of the studied model compounds on the recognition index. Data are presented as the mean ± SEM, n = 10 for each group. Letters indicate statistically significant differences between the exploration time of a novel and familiar object in the session T2 within each studied group, according to the Student’s t-test for independent samples, aaa p < 0.001, a p < 0.05 vs. familiar object. Statistical analysis of the recognition index was performed using a two-way ANOVA; symbols indicate significance of differences according to the Newman–Keuls post hoc test, *** p < 0.001, * p < 0.05 vs. control; ### p < 0.001 vs. BSO- and ∆∆∆ p < 0.001, ∆ p < 0.05 vs. GBR 12909-treated groups.