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. 2021 Jun 8;22(12):6171. doi: 10.3390/ijms22126171

Figure 4.

Figure 4

The effect of chronic administration of BSO and GBR 12909, alone or in combination, during postnatal days p5–p16, on the spontaneous and AMF-induced locomotor activity and stereotypy, measured in 90-day-old Sprague–Dawley rats using actometers. (A) Horizontal locomotor activity is presented as the total distance traveled expressed in cm, (B) vertical locomotor activity is shown as the total time spent climbing expressed in seconds (s), and (C) stereotypy as the total time devoted to stereotypical behavior expressed in seconds. These parameters were recorded during a 30–minute measurement session. Data are presented as the mean ± SEM, n = 10 for each group. Statistical analysis was performed using a two-way ANOVA; symbols indicate significance of differences according to the Newman–Keuls post hoc test, *** p < 0.001, ** p < 0.01, * p < 0.05 vs. control; ### p < 0.001, # p < 0.05 vs. BSO-; and ∆∆∆ p < 0.001, ∆ p < 0.05 vs. GBR 12909-treated groups. Comparisons between the corresponding groups treated with saline or AMF were performed using the Student’s t-test for independent samples, aaa p < 0.001 vs. saline-treated control, bbb p < 0.001 vs. saline-treated BSO group; ccc p < 0.001 vs. saline-treated GBR 12909 group; ddd p < 0.001 vs. saline-treated BSO + GBR 12909 group.