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. 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929

Figure 7.

Figure 7

IL-17 is involved in the AIA aggravation triggered by the in vivo HQ exposure. C57BL/6 WT and IL-17R−/− mice were exposed to HQ or vehicle, 1 h/day between days 15–21 after the first immunization. On the 21th day after the first immunization, animals were challenged with mBSA. Six hours later, mice were euthanized and edema (A), mechanical articular hyperalgesia (B), influx of cells into the joints (C), quantification of cytokines IL-6 (D) and IL-17 (E) and TNF-α (F), histopathological analyses (G,H) and indirect immunofluorescence analyses of NET formation by assessing the quantification of H3 citrullination (I,J) were assessed. (G): original magnification—4×. (I): original magnification—40×. Data represent mean ± SEM of four animals in each group and were analyzed by one-way ANOVA. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. HQ vehicle; # p < 0.05, ## p < 0.01 and ### p < 0.001 vs. respective group in WT mice.