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. 2021 Jun 2;8(6):469. doi: 10.3390/children8060469

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histopathology of primary central nervous system lymphoma. Hematoxylin and eosin staining of the brain biopsy specimen (A–C) shows dense infiltrates of malignant lymphocytes with a characteristic accumulation of tumor cells in the perivascular space (B, arrows) of small intraparenchymal vessels (B; arrowhead). (C) The tumor is composed of blasts with large nuclei, prominent nucleoli and frequent mitotic figures (arrowhead). (D) Expression of CD45 on malignant B cells. (E) Expression of CD20 on malignant B cells. (F) Expression of Mum1 on malignant B cells. (G) Lack of MYC expression on lymphoma cells. (H) High proliferative activity as demonstrated by Ki67/MIB-1 labelling. (I) Positive EBNA2 expression as a sign for Epstein–Barr virus infected lymphoma cells.