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. 2021 May 27;11(6):491. doi: 10.3390/life11060491

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Intestinal epithelial morphology. (A) DON resulted in disruption of intestinal morphology. H&E staining of both proximal small intestine from control, DON-treated, DON, and C60-treated mice at d14. (B) The height of the villi in the small intestine, μm. (C) Crypt depth of small intestine, μm. (D) The ratio of villi height to crypt depth in the small intestine. (E) Permeability index (LPS) in serum. (F) mRNA expression of claudin 1 genes. (G) mRNA expression of ZO-1 genes. Statistical assay used one-way ANOVA. (n = 8), four models are chosen; ^a,b,c values within a row with different superscripts differ significantly (p < 0.05).