Table 2.
Plasma concentrations of Trp metabolites in healthy controls and migraineurs in both interictal and ictal periods
| Metab. (nM) | Groups: Median ± IQR | p-values between groups | ||
|---|---|---|---|---|
| 0. Healthy Control | 1. Interictal Migraine | 2. Ictal Migraine | ||
| Trp | 53,203.65 ± 14,599.34 | 45,657.54 ± 4711.21 | 45,210.69 ± 11,292.49 | 0–1: 0.008 |
| KYN | 2505.77 ± 902.53 | 2119.41 ± 648.54 | 2418.99 ± 819.22 | 0–1: 0.003 |
| KYNA | 39.59 ± 15.32 | 33.56 ± 15.64 | 36.01 ± 10.57 | 0–1: 0.061 |
| ANA | 47.12 ± 27.79 | 35.23 ± 18.88 | 44.39 ± 28.61 | 0–1: 0.017 |
| 3-HK | 47.29 ± 27.89 | 44.79 ± 18.73 | 48.41 ± 34.54 | 0–1: 0.511 |
| XA | 17.42 ± 13.46 | 11.39 ± 5.31 | 17.61 ± 14.66 | 0–1: 0.02 |
| 3-HANA | 47.78 ± 24.59 | 44.85 ± 23.61 | 42.40 ± 21.24 | 0–1: 0.733 |
| PICA | 46.61 ± 25.63 | 34.86 ± 13.73 | 46.04 ± 24.39 |
0–1: 0.005 1–2: 0.049 |
| QUINA | 252.92 ± 169.69 | 190.86 ± 97.12 | 239.66 ± 178.05 | 0–1: 0.096 |
| 5-HT | 468.11 ± 710.24 | 772.24 ± 493.89 | 491.23 ± 509.87 | 0–1: 0.243 |
| 5-HIAA | 45.31 ± 20.46 | 37.46 ± 11.19 | 42.67 ± 11.10 | 0–1: 0.063 |
| MELA | 0.19 ± 0.11 | 0.16 ± 0.09 | 0.21 ± 0.10 | 0–1: 0.053 |
All p-values were added in the table between control and interictal group of migraine patients. Significant difference between phases of migraine was revealed only in case of PICA
IQR: interquartile range, Metab.: metabolites, Trp: Tryptophan, KYN: L-kynurenine, KYNA: Kynurenic acid, ANA: Anthranilic acid, 3-HK: 3-hydroxikynurenine, XA: Xanthurenic acid, 3-HANA: 3-hydroxi-anthranilic acid, PICA: Picolinic acid, QUINA: Quinolinic acid, 5-HT: 5-hydroxytryptamine, 5-HIAA: 5-hydroxi-indoleaceticacid, MELA: Melatonin